期刊
AMERICAN JOURNAL OF CLINICAL NUTRITION
卷 95, 期 2, 页码 465-470出版社
OXFORD UNIV PRESS
DOI: 10.3945/ajcn.111.026401
关键词
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资金
- Wellcome Trust
- International Development Research Center (Canada)
- WHO (Department of Child and Adolescent Health and Development)
- Department for International Development, United Kingdom
- European Union
- United Nations Development Fund for Women
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico/Fundacao de Aparo a Pesquisa do Estado do Rio Grande do Sul
- Brazil
- Pastorate of the Child (Brazil)
- National Council for Scientific and Technological Development (CNN
- Brazil)
- Ministry of Health (Brazil)
Background: The number of cesarean sections (CSs) is increasing in many countries, and there are concerns about their short- and long-term effects. A recent Brazilian study showed a 58% higher prevalence of obesity in young adults born by CS than in young adults born vaginally. Because CS-born individuals do not make contact at birth with maternal vaginal and intestinal bacteria, the authors proposed that this could lead to long-term changes in the gut microbiota that could contribute to obesity. Objective: We assessed whether CS births lead to increased obesity during childhood, adolescence, and early adulthood in 3 birth cohorts. Design: We analyzed data from 3 birth-cohort studies started in 1982, 1993, and 2004 in Southern Brazil. Subjects were assessed at different ages until 23 y of age. Poisson regression was used to estimate prevalence ratios with adjustment for <= 15 socioeconomic, demographic, maternal, anthropometric, and behavioral covariates. Results: In the crude analyses, subjects born by CS had similar to 50% higher prevalence of obesity at 4, 11, and 15 y of age but not at 23 y of age. After adjustment for covariates, prevalence ratios were markedly reduced and no longer significant for men or women. The only exception was an association for 4-y-old boys in the 1993 cohort, which was not observed in the other 2 cohorts or for girls. Conclusion: In these 3 birth cohorts. CSs do not seem to lead to an important increased risk of obesity during childhood, adolescence, or early adulthood. Am J Clin Nutr 2012;95:465-70.
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