期刊
AMERICAN JOURNAL OF CLINICAL NUTRITION
卷 95, 期 6, 页码 1445-1453出版社
OXFORD UNIV PRESS
DOI: 10.3945/ajcn.111.029314
关键词
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资金
- EU [LSHM_CT_2006_037197]
- Dutch Ministry of Public Health, Welfare and Sports
- Netherlands Cancer Registry
- LK Research Funds
- Dutch Prevention Funds
- Dutch Zorg Onderzoek Nederland
- World Cancer Research Fund
- Statistics Netherlands
- NL Agency [IGE05012]
- Board of the UMC Utrecht
- Cancer Research UK
- Swedish Research Council
- Novo Nordisk
- Swedish Heart Lung Foundation
- Swedish Diabetes Association
- Danish Cancer Society
- Deutsche Krebshilfe
- Associazione Italiana per la Ricerca sul Cancro
- Asturias Regional Government
- Spanish Ministry of Health
- CIBER en Epidemiologia y Salud Publica Spain
- Murcia Regional Government [6236]
- RT: AIRE-ONLUS Ragusa, AVIS-Ragusa, Sicilian Regional Government
- MRC [MC_UP_A100_1003] Funding Source: UKRI
- Medical Research Council [MC_UP_A100_1003, MC_U106179471] Funding Source: researchfish
Background: Epidemiologic evidence of an association between fish intake and type 2 diabetes (T2D) is inconsistent and unresolved. Objective: The objective was to examine the association between total and type of fish intake and T2D in 8 European countries. Design: This was a case-cohort study, nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study, with 3.99 million person-years of follow-up, 12,403 incident diabetes cases, and a random subcohort of 16,835 individuals from 8 European countries. Habitual fish intake (lean fish, fatty fish, total fish, shellfish, and combined fish and shellfish) was assessed by country-specific dietary questionnaires. HRs were estimated in each country by using Prentice-weighted Cox regression models and pooled by using a random-effects meta-analysis. Results: No overall association was found between combined fish and shellfish intake and incident T2D per quartile (adjusted HR: 1.00; 95% Cl: 0.94, 1.06; P-trend = 0.99). Total fish, lean fish, and shellfish intakes separately were also not associated with T2D, but fatty fish intake was weakly inversely associated with T2D: adjusted HR per quartile 0.97 (0.94, 1.00), with an HR of 0.84 (0.70, 1.01), 0.85 (0.76, 0.95), and 0.87 (0.78, 0.97) for a comparison of the second, third, and fourth quartiles with the lowest quartile of intake, respectively (P-trend = 0.06). Conclusions: These findings suggest that lean fish, total fish, and shellfish intakes are not associated with incident diabetes but that fatty fish intake may be weakly inversely associated. Replication of these findings in other populations and investigation of the mechanisms underlying these associations are warranted. Meanwhile, current public health recommendations on fish intake should remain unchanged. Am J Clin Nutr 2012;95:1445-53,
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