期刊
AMERICAN JOURNAL OF CLINICAL NUTRITION
卷 92, 期 6, 页码 1501-1510出版社
OXFORD UNIV PRESS
DOI: 10.3945/ajcn.2010.29836
关键词
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资金
- Canadian Diabetes Association [OG 2 09 2826]
- Advanced Foods and Materials Network [305352]
Background Taste is an important determinant of food consumption and genetic variations in the sweet taste receptor subunit TASIR2 may contribute to Interindividual variations in sugar consumption Objective We determined whether Ser9Cys and Ile191Val variations in TASIR2 were associated with differences in the consumption of sugars in 2 populations Design Population 1 included 1037 diabetes free young adults in whom we assessed dietary intake by using a I mo 196 item food frequency questionnaire Population 2 consisted of 100 individuals with type 2 diabetes with dietary intakes assessed by using 2 sets of 3 d food records administered 2 wk apart Dietary counseling was provided between food records 1 and 2 Dietary intakes between genotypes were compared by using analysis of covariance adjusted for potential confounders Results In population 1 a significant Ile191Val x body mass index (BMI in kg/m(2)) interaction was detected for the consumption of sugars and the effect of genotype was significant only in individuals with a BMI >= 25 (n = 205) In comparison with individuals homo zygous for the Ile allele Val earners consumed fewer sugars (122 +/- 6 compared with 103 +/- 6 g sugar/d respectively P = 0 01) Regression estimates that associated BMI with total sugar con sumption by Ile/Ile and Val carrier genotype intersected at a BMI of 23 5 In population 2 Val carriers also consumed less sugar than did individuals with the Ile/Ile genotype (99 6 compared with 83 6 g sugar/d respectively P = 0 04) on food record 2 and sugar was the only macronutrient that decreased significantly (-9 +/- 4 g suear/d P = 0 02) in Val carriers who received dietary counseling Conclusion Our findings show that I genetic variation in TASIR2 affects habitual consumption of sugars and may contribute to interindividual differences in changing behaviors in response to dietary counseling Am J Chu Nutr 2010 92 1501-10
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