期刊
AMERICAN JOURNAL OF CLINICAL NUTRITION
卷 90, 期 3, 页码 595-601出版社
OXFORD UNIV PRESS
DOI: 10.3945/ajcn.2008.27382
关键词
-
资金
- Diabetes Prevention Program, National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Child Health and Human Development
- National Institute on Aging
- The Office of Research on Minority Health and Health Disparities
- Office of Women's Health
- Indian Health Service
- Centers for Disease Control and Prevention
- General Clinical Research
- National Center for Research Resources
- American Diabetes Association
- Bristol-Myers Squibb
- Lipha Pharmaceuticals, Inc
- Parke-Davis. LifeScan Inc
- Health O Meter, Hoechst Marion Roussel, Inc
- Merck-Medco Managed Care Inc
- Merck and Co
- Nike Sports Marketing
- Slim Fast Foods Co
- Quaker Oats Co donated the materials, equipment
Background: Moderate alcohol consumption is associated with a decreased risk of type 2 diabetes in the general population, but little is known about the effects in individuals at high risk of diabetes. Objectives: The objectives were to determine associations between alcohol consumption and diabetes risk factors and whether alcohol consumption was a predictor of incident diabetes in individuals enrolled in the Diabetes Prevention Program (DPP). Design: DPP participants (n = 3175) had impaired glucose tolerance (2-h glucose: 7.8-11.1 mmol/L), elevated fasting glucose (5.3-7.0 mmol/L), and a body mass index (in kg/m(2)) >= 24. Participants were randomly assigned to placebo, metformin, or lifestyle modification and were followed for a mean of 3.2 y. Alcohol intake was assessed at baseline and year 1 by using a semiquantitative food-frequency questionnaire. Diabetes was diagnosed by annual oral-glucose-tolerance testing and semiannual fasting plasma glucose measurement. Results: Participants who reported higher alcohol consumption tended to be male, older, white, and less obese and to have a higher calorie intake and a higher HDL-cholesterol concentration. Higher alcohol consumption was associated with lower insulin secretion at any level of insulin sensitivity. We found lower incidence rates of diabetes with higher alcohol consumption in the metformin (P < 0.01 for trend) and lifestyle modification (P = 0.02 for trend) groups, which remained significant after adjustment for multiple baseline covariates. No similar association was observed in the placebo group. Conclusions: Despite overall low rates of alcohol consumption, there was a reduced risk of incident diabetes in those who reported modest daily alcohol intake and were assigned to metformin or lifestyle modification. Moderate daily alcohol intake is associated with lower insulin secretion-an effect that warrants further investigation. This trial was registered at clinicaltrials.gov as NCT00038727. Am J Clin Nutr 2009;90:595-601.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据