期刊
AMERICAN JOURNAL OF CLINICAL NUTRITION
卷 88, 期 6, 页码 1567-1575出版社
AMER SOC CLINICAL NUTRITION
DOI: 10.3945/ajcn.2008.26205
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资金
- Cancer Research UK
- European Commission
- German Cancer Aid
- German Cancer Research Center
- German Federal Ministry of Education and Research
- Danish Cancer Society
- Health Research Fund of the Spanish Ministry of Health
- CIBER Epidemiologia y Salud Publica, Barcelona, Spain
- participating regional governments and institutions of Spain
- Medical Research Council, United Kingdom
- Stroke Association
- United Kingdom
- British Heart Foundation
- Department of Health, United Kingdom
- Food Standards Agency, United Kingdom
- Greek Ministry of Education
- Greek Ministry of Health and Social Solidarity
- Hellenic Health Foundation
- Italian Association for Research on Cancer
- Italian National Research Council
- Dutch Ministry of Public Health, Welfare and Sports
- Dutch Ministry of Health
- Dutch Prevention Funds
- LK Research Funds
- Dutch Zorg Onderzoek Nederland
- World Cancer Research Fund
- Swedish Cancer Society
- Swedish Scientific Council
- Regional Government of Skane, Sweden
- MRC [G0501019] Funding Source: UKRI
- Medical Research Council [G0501019] Funding Source: researchfish
Background: Some evidence indicates that a low selenium intake may be associated with an increased risk of prostate cancer. Objective: The aim of this study was to investigate the association of plasma selenium concentration with subsequent prostate cancer risk and to examine this association by stage and grade of disease and other factors. Design: A nested case-control study was performed among men in the European Prospective Investigation into Cancer and Nutrition (EPIC). The association between plasma selenium concentration and prostate cancer risk was assessed in 959 men with incident prostate cancer and 1059 matched controls. Results: Overall, plasma selenium concentration was not associated with prostate cancer risk; the multivariate relative risk for men in the highest fifth of selenium concentration compared with the lowest fifth was 0.96 (95% CI: 0.70, 1.31; P for trend = 0.25). There were no significant differences in the association of plasma selenium with risk when analyzed by stage or grade of disease. Similarly, the association of selenium with risk did not differ by smoking status or by plasma alpha- or gamma-tocopherol concentration. Conclusion: Plasma selenium concentration was not associated with prostate cancer risk in this large cohort of European men. Am J Clin Nutr 2008; 88:1567-75.
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