期刊
AMERICAN JOURNAL OF CLINICAL NUTRITION
卷 89, 期 1, 页码 391-399出版社
AMER SOC CLINICAL NUTRITION
DOI: 10.3945/ajcn.2008.26363
关键词
-
资金
- US Department of Agriculture Agricultural Research Service [53-K06-5-10 and 58-1950-9-001]
- NIH Heart, Lung, and Blood Institute [U 01 HL72524]
- Genetic and Environmental Determinants of Triglycerides
- NIH, National Institute on Aging [5P01AG023394-02, RD07/0067/0006, PR2008-0268]
- Instituto de Salud Carlos III, Spain [CIBEROBN03/06, PI070954]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [U01HL072524] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [P01AG023394] Funding Source: NIH RePORTER
Background: Hypertriglyceridemia is a risk factor for cardiovascular disease. Variation in the apolipoprotein A5 (APOA5) and glucokinase regulatory protein (GCKR) genes has been associated with fasting plasma triacylglycerol. Objective: We investigated the combined effects of the GCKR rs780094C -> T, APOA5 -1131T -> C, and APOA5 56C -> G single nucleotide polymorphisms (SNPs) on fasting triacylglycerol in several independent populations and the response to a high-fat meal and fenofibrate interventions. Design: We used a cross-sectional design to investigate the association with fasting triacylglycerol in 8 populations from America, Asia, and Europe (n = 7730 men and women) and 2 intervention studies in US whites (n = `1061) to examine postprandial triacylglycerol after a high-fat meal and the response to fenofibrate. We defined 3 combined genotype groups: 1) protective (homozygous for the wild-type allele for all 3 SNPs); 2) intermediate (any mixed genotype not included in groups 1 and 3); and 3) risk (carriers of the variant alleles at both genes). Results: Subjects within the risk group had significantly higher fasting triacylglycerol and a higher prevalence of hypertriglyceridemia than did subjects in the protective group across all populations. Moreover, subjects in the risk group had a greater postprandial triacylglycerol response to a high-fat meal and greater fenofibrate-induced reduction of fasting triacylglycerol than did the other groups, especially among persons with hypertriglyceridemia. Subjects with the intermediate genotype had intermediate values (P for trend < 0.001). Conclusions: SNPs in GCKR and APOA5 have an additive effect on both fasting and postprandial triacylglycerol and contribute to the interindividual variability in response to fenofibrate treatment. Am J Clin Nutr 2009;89:391-9. Clin Nutr 2009; 89: 391-9.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据