期刊
AMERICAN JOURNAL OF CLINICAL NUTRITION
卷 87, 期 5, 页码 1194-1203出版社
OXFORD UNIV PRESS
DOI: 10.1093/ajcn/87.5.1194
关键词
-
资金
- NCCIH NIH HHS [1R21AT002993, 1R21AT003545, 5R21AT2500, R21 AT002993] Funding Source: Medline
- NCRR NIH HHS [UL1 RR024146-01, UL1 RR024146] Funding Source: Medline
- NHLBI NIH HHS [R01 HL107256, R01 HL075675-01A1, R01 HL091333, R01 HL075675] Funding Source: Medline
Background: We have reported that, compared with glucose-sweetened beverages, consuming fructose-sweetened beverages with meals results in lower 24-h circulating glucose, insulin, and leptin concentrations and elevated triacylglycerol (TG). However, pure fructose and glucose are not commonly used as sweeteners. High-fructose corn syrup (HFCS) has replaced sucrose as the predominant sweetener in beverages in the United States. Objective: We compared the metabolic/endocrine effects of HFCS with sucrose and, in a subset of subjects, with pure fructose and glucose. Design: Thirty-four men and women consumed 3 isocaloric meals with either sucrose- or HFCS-sweetened beverages, and blood samples were collected over 24 h. Eight of the male subjects were also studied when fructose- or glucose-sweetened beverages were consumed. Results: In 34 subjects, 24-h glucose, insulin, leptin, ghrelin, and TG profiles were similar between days that sucrose or HFCS was consumed. Postprandial TG excursions after HFCS or sucrose were larger in men than in women. In the men in whom the effects of 4 sweeteners were compared, the 24-h glucose and insulin responses induced by HFCS and sucrose were intermediate between the lower responses during consumption of fructose and the higher responses during glucose. Unexpectedly, postprandial TG profiles after HFCS or sucrose were not intermediate but comparably high as after pure fructose. Conclusions: Sucrose and HFCS do not have substantially different short-term endocrine/metabolic effects. In male subjects, short-term consumption of sucrose and HFCS resulted in postprandial TG responses comparable to those induced by fructose.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据