期刊
AMERICAN JOURNAL OF CLINICAL NUTRITION
卷 88, 期 6, 页码 1653-1662出版社
OXFORD UNIV PRESS
DOI: 10.3945/ajcn.2008.26398
关键词
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资金
- III (ISCIII) Network Red Centros de Investigacion Cooperativa en Epidemiologia y Salud Publica, Spain [C03/09]
- Cancer Research UK
- Medical Research Council, United Kingdom
- Food Standards Agency, United Kingdom
- Wellcome Trust, United Kingdom
- Greek Ministry of Health and Social Solidarity
- Hellenic Health Foundation
- Italian Association for Research on Cancer
- Italian National Research Council
- Dutch Ministry of Public Health, Welfare, and Sports
- Dutch Ministry of Health
- Dutch Prevention Funds
- LK Research Funds
- Dutch Zorg Onderzoek Nederland
- World Cancer Research Fund
- Swedish Cancer Society
- Swedish Scientific Council
- Regional Government of Skane, Sweden
- Norwegian Cancer Society
- National Cancer Institute [R37 CA054281]
- German Research Foundation
- European Commission
- Ligue contre le Cancer, France
- Societe 3M, France
- Mutuelle Generale de l'Education Nationale
- Institut National de la Sante et de la Recherche Medicale
- German Cancer Aid
- German Cancer Research Center
- German Federal Ministry of Education and Research
- Danish Cancer Society
- Spanish Ministry of Health
- Instituto de Salud Carlos III (ISCIII) Network Red Centros de Investigacion Cooperativa en Epidemiologia y Salud Publica, Spain [C03/09]
- Dutch Ministry of Public Health, Welfare, and Sports
- Dutch Ministry of Health
- Dutch Prevention Funds
Background: In the Multiethnic Cohort (MEC) study, we showed inverse associations between flavonols and pancreatic cancer risk. Objective: We aimed to define a food pattern associated with intakes of quercetin, kaempferol, and myricetin; to examine the association of that pattern with pancreatic cancer risk; and to investigate the associations in an independent study. Design: Reduced rank regression was applied to dietary data for 183 513 participants in the MEC. A food group pattern was extracted and simplified and applied to dietary data of 424 978 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Dietary intake in both studies was assessed by using specially developed questionnaires. Multivariate Cox proportional hazards models were used to estimate relative risks for pancreatic cancer in the MEC (610 cases) and the EPIC (517 cases) studies. Results: The food group pattern consisted mainly of tea, fruit, cabbage, and wine. In the MEC, inverse associations with pancreatic cancer in smokers were observed for the food group pattern [relative risk: 0.59 (95% CI: 0.31, 1.12) when extreme quintiles were compared; P for trend = 0.03]. In the EPIC study, the simplified pattern was not associated with pancreatic cancer risk (P for trend = 0.78). Conclusions: A food pattern associated with the intake of quercetin, kaempferol, and myricetin was associated with lower pancreatic cancer risk in smokers in a US-based population. However, failure to replicate the associations in an independent study weakens the conclusions and raises questions about the utility of food patterns for flavonols across populations. Am J Clin Nutr 2008; 88: 1653-62.
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