期刊
AMERICAN JOURNAL OF CARDIOLOGY
卷 113, 期 12, 页码 2057-2063出版社
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
DOI: 10.1016/j.amjcard.2014.03.048
关键词
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资金
- NHLBI [N01HC 25195, 1R01HL60040, 1R01HL70100]
- USEPA [RD834798]
- NIEHS [ES009825, ES022243, ES023352, ES000002]
- Swedish Council for Working Life and Social Research
- Marie Curie International Postdoctoral Fellowship Programme
- Swedish Heart-Lung Foundation
- Swedish Society of Cardiology
- Swedish Society for Medical Research
Long-term exposure to ambient air pollution has been associated with cardiovascular morbidity and mortality. Impaired vascular responses may, in part, explain these findings, but the association of such long-term exposure with measures of both conduit artery and microvascular function has not been widely reported. We evaluated the association between residential proximity to a major roadway (primary or secondary highway) and spatially resolved average fine particulate matter (PM2.5) and baseline brachial artery diameter and mean flow velocity, flow-mediated dilation%, and hyperemic flow velocity, in the Framingham Offspring and Third Generation Cohorts. We examined 5,112 participants (2,731 [53%] women, mean age 49 +/- 14 years). Spatially resolved average PM2.5 was associated with lower flow-mediated dilation% and hyperemic flow velocity. An inter-quartile range difference in PM2.5 (1.99 mu g/m(3)) was associated with -0.16% (95% confidence interval [CI] -0.27%, -0.05%) lower flow-mediated dilation% and -0.72 (95% CI -1.38, -0.06) cm/s lower hyperemic flow velocity%. Residential proximity to a major roadway was negatively associated with flow-mediated dilation%. Compared with living 400 m away, living <50 m from a major roadway was associated with 0.32% lower flow mediated dilation (95% CI -0.58%, -0.06%), but results for hyperemic flow velocity had wide confidence intervals -0.68 cm/s (95% CI -2.29, 0.93). In conclusion, residential proximity to a major roadway and higher levels of spatially resolved estimates of PM2.5 at participant residences are associated with impaired conduit artery and microvascular function in this large community-based cohort of middle-aged and elderly adults. (C) 2014 Elsevier Inc. All rights reserved.
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