期刊
AMERICAN JOURNAL OF CARDIOLOGY
卷 106, 期 3, 页码 360-368出版社
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
DOI: 10.1016/j.amjcard.2010.03.032
关键词
-
资金
- National Institutes of Health, Bethesda, Maryland [HL-075173, HL-080144, HL-090842]
- American Heart Association, Dallas, Texas [0640084N]
- American Diabetes Association, Alexandria, Virginia [7-08-MN-21-ADA]
- AHA-Jon Holden DeHaan Foundation, Naples, Florida [0970518N]
- Schering-Plough Corporation, Kenilworth, New Jersey
Since the initial description of the phenomenon by Jennings et al 50 years ago, our understanding of the underlying mechanisms of reperfusion injury has grown significantly. Its pathogenesis reflects the confluence of multiple pathways, including ion channels, reactive oxygen species, inflammation, and endothelial dysfunction. The purposes of this review are to examine the current state of understanding of ischemia-reperfusion injury, as well as to highlight recent interventions aimed at this heretofore elusive target. In conclusion, despite its complexity our ongoing efforts to mitigate this form of injury should not be deterred, because nearly 2 million patients annually undergo either spontaneous (in the form of acute myocardial infarction) or iatrogenic (in the context of cardioplegic arrest) ischemia-reperfusion. (C) 2010 Elsevier Inc. All rights reserved. (Am J Cardiol 2010;106: 360-368)
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据