期刊
AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS
卷 27, 期 7, 页码 474-482出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1533317512456449
关键词
Alzheimer's disease; caregiver burden; caregiver-perceived burden questionnaire; patient-reported outcomes (PROs); caregiver-reported outcomes (CROs); PRO instrument development; PRO instrument validation
资金
- Forest Laboratories, Jersey City, New Jersey
Objective: To validate the Caregiver-Perceived Burden Questionnaire (CPBQ) and report its psychometric properties. Methods: The CPBQ was administered to caregivers of patients with moderate-to-severe AD in a double-blind randomized trial comparing extended-release memantine to placebo (n = 676). Measurement properties were analyzed using factor analysis, classical test theory, and Rasch analysis. Results: Two subscales were identified: the Caregivers' Assessment of the Patient (CAP) and the Caregivers' Assessment of Themselves (CAT). The reliability was .89 (CAP) and .83 (CAT). The CAP scores were significantly correlated (r > .3) with scores from the Severe Impairment Battery (SIB) and the Neuropsychiatric Inventory (NPI). The CAT scores were significantly correlated with NPI scores. The CAT discriminated among patients by clinician-rated severity and significantly differentiated between responders and nonresponders. Conclusion: The CPBQ appears to be a reliable, valid, and responsive measure that enables linking caregiver's perceptions about burden and patient function in patients with moderate-to-severe AD.
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