期刊
AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS
卷 23, 期 1, 页码 97-102出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1533317507310565
关键词
alpha-synuclein; beta-amyloid; dementia with; Lewy bodices; Braak staged; synapse; synaptic loss; tau
Synaptic loss is present in Alzheimer's disease and correlates with the severity of dementia. Loss of synapses in dementia with Lewy bodies (DLB) does not correlate as clearly with cognitive Status and its cause is unclear. To begin to understand the relationship between cognition and synaptic loss in DLB, we assessed immunoreactivity for the synaptic-terminal specific protein, synaptophysin, in the hippocampus in 14 DLB cases. Quantitative synaptic data were obtained using in Image-Pro semiautomated analysis system. We determined Braak stage, beta-amyloid, Lewy bodies (LBs), and Lewy, neurites (LN). We found significant correlations (r = 0.6 17, P <.01) between Braak stage and synaptophysin,sin score and marginal correlation between LN score and synaptophysin loss (r = 0.694, P <.06). Correlations of beta-amyloid and of LB density with synaptophysin score were unimpressive. These data Support the hypothesis that synaptic loss in DLB is related to neuritic degeneration.
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