期刊
AMERICAN HEART JOURNAL
卷 155, 期 3, 页码 478-484出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.ahj.2007.10.026
关键词
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资金
- NHLBI NIH HHS [N01 HC055144, R01 HL065176, R01 HL073211-05, N01 HC055145, N01 HC055142, N01 HC055146, N01 HC055141, N01 HC055148, N01 HC055143, R01 HL073211, N01 HC055140, R01 HL065176-07, N01 HC055147] Funding Source: Medline
- NIMHD NIH HHS [P20 MD002329] Funding Source: Medline
Background The relationship of changes in weight to outcomes in patients after myocardial infarction (MI) is controversial. Methods From the ENRICHD trial data, we assessed weight change, and the associations of baseline weight and change at follow-up with outcomes and interactions between psychosocial factors. Results At baseline, 73.6% of patients (n = 1706) were overweight or obese; 134 patients had body mass index of >= 40. Underweight patients were more likely to die or have nonfatal recurrent MI. After controlling for covariates, overweight and obese patients had similar outcomes to normal-weight patients. Eighteen percent of patients gained >5%, 27% lost >5%, and 55% had <= 5% change in weight. Compared with weight loss of <= 55%, the risk of death (adjusted hazard ratio 1.74, P = .01) and cardiovascular death (hazard ratio 1.79, P = .04) increased with weight, loss of >5%. After propensity matching, weight loss of >5% remained as a significant risk factor for death and cardiovascular death. There was no interaction between weight change and depression and/or social support at baseline or follow-up. Weight change was not associated with recurrent MI or cardiovascular hospitalizations. Conclusions A large proportion of patients lose or gain >5% of body weight after an MI. The association between obesity and lower mortality is modulated by comorbidities. Weight loss after MI is associated with worse outcomes and is not related to depression or social support.
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