期刊
ALZHEIMERS & DEMENTIA
卷 10, 期 6, 页码 799-807出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jalz.2014.05.1749
关键词
Plasma; Mild cognitive impairment; Pathology; Alzheimer's disease; Biomarker; Prediction and magnetic resonance imaging
资金
- Medical Research Council (MRC) UK [G0801464]
- Alzheimer's Research UK (ARUK)
- National Institute for Health Research (NIHR) Biomedical Research Centre, Biomedical Research Unit for Dementia
- Innovative Medicines Initiative Joint Undertaking under EMIF grant [115372]
- European Union
- EFPIA companies
- EU
- MRC [G0801464] Funding Source: UKRI
- Alzheimers Research UK [ARUK-EXT2013-4, ART-PG2010-4] Funding Source: researchfish
- Alzheimer's Society [171] Funding Source: researchfish
- Medical Research Council [G0801464] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0512-10053] Funding Source: researchfish
Background: The study aimed to validate previously discovered plasma biomarkers associated with AD, using a design based on imaging measures as surrogate for disease severity and assess their prognostic value in predicting conversion to dementia. Methods: Three multicenter cohorts of cognitively healthy elderly, mild cognitive impairment (MCI), and AD participants with standardized clinical assessments and structural neuroimaging measures were used. Twenty-six candidate proteins were quantified in 1148 subjects using multiplex (xMAP) assays. Results: Sixteen proteins correlated with disease severity and cognitive decline. Strongest associations were in the MCI group with a panel of 10 proteins predicting progression to AD (accuracy 87%, sensitivity 85%, and specificity 88%). Conclusions: We have identified 10 plasma proteins strongly associated with disease severity and disease progression. Such markers may be useful for patient selection for clinical trials and assessment of patients with predisease subjective memory complaints. (C) 2014 The Authors. Published by Elsevier Inc. on behalf of The Alzheimer's Association. This is an open access article under the CC BY license.
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