期刊
ALZHEIMERS & DEMENTIA
卷 10, 期 3, 页码 S196-S212出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jalz.2014.04.015
关键词
Alzheimer's disease; Alzheimer's Disease Neuroimaging Initiative; Amyloid-beta; Apolipoprotein E epsilon 4; Asymptomatic; Cerebrospinal fluid biomarkers; Epigenomics; Metabolomics; Mild cognitive impairment; Neuroimaging biomarkers; Peripheral blood biomarkers; Preclinical; Proteomics; Tau; Transcriptomics
资金
- United States Army Medical Research and Materiel Command
The increasing number of afflicted individualswith late-onset Alzheimer's disease (AD) poses significant emotional and financial burden on the world's population. Therapeutics designed to treat symptoms or alter the disease course have failed to make an impact, despite substantial investments by governments, pharmaceutical industry, and private donors. These failures in treatment efficacy have led many to believe that symptomatic disease, including both mild cognitive impairment (MCI) and AD, may be refractory to therapeutic intervention. The recent focus on biomarkers for defining the preclinical state of MCI/AD is in the hope of defining a therapeutic window in which the neural substrate remains responsive to treatment. The ability of biomarkers to adequately define the at-risk state may ultimately allow novel or repurposed therapeutic agents to finally achieve the disease-modifying status for AD. In this review, we examine current preclinical AD biomarkers and suggest how to generalize their use going forward. (C) 2014 The Alzheimer's Association. All rights reserved.
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