Severe Acquired Toxoplasmosis Caused by Wild Cycle of Toxoplasma gondii, French Guiana

From 1998 through 2006, 44 cases of severe primary toxoplasmosis were observed in French Guiana in immunocompetent adults. Toxoplasma gondii isolates exhibited an atypical multilocus genotype. Severe disease in humans may result from poor host adaptation to neotropical zoonotic strains of T gondii circulating in a forest-based cycle.