期刊
INTERNATIONAL JOURNAL OF CARDIOLOGY
卷 184, 期 -, 页码 446-451出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ijcard.2015.02.084
关键词
Bone marrow mononuclear cells; Hypoxia-preconditioning; Acute myocardial infarction
资金
- National High-Tech R&D Program (863 Program) [N20130685]
- Major National Scientific Research Plan (973 Program [2014CB965100]
- National Natural Science Foundation of China [31171418, 81170308]
- Major Innovation Team of Zhejiang province [2010R50047]
- Major Project of Science Technology Department of Zhejiang province [2012C13013-3]
Background: Pre-clinical studies have shown that hypoxia preconditioning can enhance stem cell therapeutic potential for myocardial repair. We sought to investigate the safety and feasibility of intracoronary administration of hypoxia-preconditioned bone marrow mononuclear cells (HP-BMCs) for acute ST segment elevation myocardial infarction (STEMI). Methods: We randomized 22 patients with acute STEMI to receive intracoronary administration of normoxia bone marrow mononuclear cells (N-BMCs) (n= 11) or HP-BMCs (n= 11) following successful reperfusion. Another 14 patients receiving standard therapy were recruited as control (n= 14). Results: There were no differences in the occurrence of major adverse cardiovascular events at 30 days and 1 year among three groups. There were significant improvement in the change of left ventricular end-diastolic volume (LVEDV) and end-systolic volume (LVESV) inHP-BMC group both at 6 and 12 months compared with N-BMCs or control group (P < 0.05). No differences were observed in the change of left ventricular ejection fraction (LVEF), or wall motion score index (WMSI) among three groups. Nevertheless, WMSI was improved in HP-BMCs and NBMC group (P < 0.05, within group), but not in control. The ratio of myocardial perfusion defect determined by SPECT was significantly decreased in HP-BMCs and N-BMC groups at 6 months compared with baseline (P < 0.05, within group), but no significant differences were observed among three groups. Conclusions: Our results provide the first-in-man evidence that intracoronary administration of HP-BMCs following acute MI appears to be safe and feasible. These results provide the basis for future prospective randomized clinical trials in a larger patient cohort. (c) 2015 The Authors. Published by Elsevier Ireland Ltd.
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