期刊
ALZHEIMERS & DEMENTIA
卷 10, 期 6, 页码 769-778出版社
WILEY
DOI: 10.1016/j.jalz.2014.06.002
关键词
Cognitive decline; Dementia; Type 2 diabetes; Elderly; Cognitively normal; Risk factors; Study design
资金
- National Institute on Aging [R01 AG034087, P50 AG05138]
- Ira T. Hirschl Award
- Helen Bader Foundation
- Leroy Schecter Foundation
Background: Type 2 diabetes (T2D) is associated with increased risk of dementia. The prospective longitudinal Israel Diabetes and Cognitive Decline study aims at identifying T2D-related characteristics associated with cognitive decline. Methods: Subjects are population-based T2D 65+, initially cognitively intact. Medical conditions, blood examinations, and medication use data are since 1998; cognitive, functional, demographic, psychiatric, DNA, and inflammatory marker study assessments were conducted every 18 months. Because the duration of T2D reflects its chronicity and implications, we compared short (0-4.99 years), moderate (5-9.99), and long (10+) duration for the first 897 subjects. Results: The long duration group used more T2D medications, had higher glucose, lower glomerular filtration rate, slower walking speed, and poorer cognitive functioning. Duration was not associated with most medical, blood, urine, and vital characteristics. Conclusions: Tracking cognition, with face-to-face evaluations, exploiting 15 years of historical detailed computerized, easily accessible, and validated T2D-related characteristics may provide novel insights into T2D-related dementia. (C) 2014 The Alzheimer's Association. All rights reserved.
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