期刊
ALZHEIMERS & DEMENTIA
卷 8, 期 6, 页码 483-489出版社
WILEY
DOI: 10.1016/j.jalz.2011.08.008
关键词
Alzheimer disease; Vascular risk factors; PiB; Amyloid-beta; Cortisol; Blood pressure; Body mass index
资金
- ADNI [U01 AG024904]
- National Institute on Aging
- National Institute of Biomedical Imaging and Bioengineering
- Foundation for the National Institutes of Health
- Alfonso Martin Escudero Foundation
- DOD
- Merck
- Avid
- VA
- [AG10124]
Background: There is epidemiological evidence that cardiovascular risk factors (CVRF) also are risk factors for Alzheimer's disease, but there is limited information on this from neuropathological studies, and even less from in vivo studies. Therefore, we examined the relationship between CVRF and amyloid-beta (A beta) brain burden measured by Pittsburgh Compound B-positron emission tomography (PiB-PET) studies in the Alzheimer's Disease Neuroimaging Initiative. Methods: Ninety-nine subjects from the Alzheimer's Disease Neuroimaging Initiative cohort who had a PiB-PET study measure, apolipoprotein E genotyping data, and information available on CVRF (body mass index [BMI], systolic blood pressure, diastolic blood pressure [DBP], and cholesterol and fasting glucose test results) were included. Eighty-one subjects also had plasma cortisol, C-reactive protein, and superoxide dismutase 1 measurements. Stepwise regression models were used to assess the relation between the CVRF and the composite PiB-PET score. Results: The first model included the following as baseline variables: age, clinical diagnosis, number of apolipoprotein epsilon 4 alleles, BMI (P = .023), and DBP (P = .012). BMI showed an inverse relation with PiB-PET score, and DBP had a positive relation with PiB-PET score. In the second adjusted model, cortisol plasma levels were also associated with PiB-PET score (P = .004). Systolic blood pressure, cholesterol, or impaired fasting glucose were not found to be associated with PiB-PET values. Conclusion: In this cross-sectional study, we found an association between A beta brain burden measured in vivo and DBP and cortisol, indicating a possible link between these CVRF and A beta burden measured by PiB-PET. These findings highlight the utility of biomarkers to explore potential pathways linking diverse Alzheimer's disease risk factors. (C) 2012 The Alzheimer's Association. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据