期刊
CURRENT COLORECTAL CANCER REPORTS
卷 5, 期 2, 页码 69-74出版社
SPRINGER
DOI: 10.1007/s11888-009-0011-z
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资金
- NCI NIH HHS [R01 CA084197, R01 CA084197-11] Funding Source: Medline
- NIDDK NIH HHS [R01 DK052230-13, R01 DK052230, R24 DK064399-07, K01 DK076742-03, K01 DK076742, R24 DK064399] Funding Source: Medline
Chronic inflammatory disorders are often associated with an increased risk of developing cancer. A classic example of the connection between inflammation and cancer is the increased risk of colorectal cancer in patients with inflammatory bowel disease (IBD). In this review, we discuss aspects of IBD that promote colorectal cancer and highlight key molecular mediators that contribute to cancer risk. Additionally, we report on progress in identifying molecular targets that may prove efficacious in blocking the progression of IBD-related inflammation to cancer.
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