期刊
ALZHEIMERS & DEMENTIA
卷 5, 期 3, 页码 227-233出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jalz.2009.01.026
关键词
Prevalence rates; Alzheimer's disease; African Americans; 1992 vs 2001; Population-based
资金
- NIA NIH HHS [R01 AG 009956-17, R01 AG009956, R01 AG009956-16] Funding Source: Medline
Background: This study compares age-specific and overall prevalence rates for dementia and Alzheimer's disease (AD) in two nonoverlapping, population-based cohorts of elderly African Americans in Indianapolis in 2001 and 1992. Methods: We used a two-stage design. The first stage involves the Community Screening Interview for Dementia (CSI-D). The CSI-D scores are grouped into good, intermediate, and poor performance before selection for clinical assessment. Diagnoses were performed using standard criteria in a consensus diagnosis conference; clinicians were blind to performance groups. In 1992, interviewers visited randomly sampled addresses to enroll self-identified African Americans aged >= 65 years. Of 2582 eligible, 2212 enrolled (9.6% refused, and 4.7% were too sick). In 2001, Medicare rolls were used for African Americans aged >70 years. Of 4260 eligible, 1892 (44%) enrolled, 1999 (47%) refused, and the remainder did not participate for other reasons. Results: The overall age-adjusted prevalence rate for dementia at age 70 years in 2001 was 7.45% (95 confidence interval [CI], 4.27-10.64). and in the 1992 cohort, this prevalence rate was 6.75% (95% CI, 5.77-7.74). The overall age-adjusted prevalence rate at age >= 70 years for AD in the 2001 cohort was 6.77% (95% CI, 3.65-9.90), and for the 1992 cohort, it was 5.47% (95% CI, 4.51-6.42). Rates for dementia and AD were not significantly different in the two cohorts (dementia, P = .3534; AD, P = .2649). Conclusions: We found no differences in the prevalence rates of dementia and AD between 1992 and 2001, despite significant differences in medical history and medical treatment within these population-based cohorts of African American elderly. (C) 2009 The Alzheimer's Association. All rights reserved.
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