期刊
JOURNAL OF ABNORMAL PSYCHOLOGY
卷 118, 期 2, 页码 335-347出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/a0015636
关键词
alcohol; startle response; anxiety; fear; stress response dampening
资金
- NIAAA NIH HHS [R01 AA015384, R01 AA015384-03, R01AA15384] Funding Source: Medline
- NIMH NIH HHS [5T32MH018931-18, T32 MH018931-17, T32 MH018931, T32 MH018931-18] Funding Source: Medline
Recent theory and empirical research have suggested that fear and anxiety are distinct processes with separable neurobiological substrates. Furthermore, a laboratory procedure has been developed to manipulate fear versus anxiety independently via administration of predictable or unpredictable electric shock, respectively. Benzodiazepines appear to selectively reduce anxiety but not fear in this procedure. The primary aim of this experiment was to determine if alcohol produced a similar selective reduction in anxiety. Intoxicated (target blood alcohol concentration of .08%) and nonintoxicated participants viewed a series of colored squares separated by variable intertrial intervals (ITIs) in 3 conditions. In the predictable shock condition, shocks were administered contingently during every square. In the unpredictable shock condition, shocks were administered noncontingently during both squares and ITIs. In the no-shock condition, no shocks were administered at any time. Alcohol significantly reduced startle potentiation during cues signaling unpredictable but not predictable shock, consistent with the thesis that alcohol selectively reduces anxiety but not fear. In addition, alcohol's effect on startle potentiation during unpredictable shock was mediated by vigilance. This anxiolytic effect may clarify the nature of alcohol's reinforcing effects in social and problem drinkers.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据