期刊
ALZHEIMER DISEASE & ASSOCIATED DISORDERS
卷 26, 期 2, 页码 179-185出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WAD.0b013e3182211ab1
关键词
Tg2576 mice; aluminum; functional observational battery; novel object recognition; beta-amyloid; corticosterone
资金
- Fondo de Investigacion Sanitaria-FIS [PI041673]
The role of aluminum (Al) in Alzheimer disease is highly controversial. However, this element has been detected in neuritic plaques and neurofibrillary tangles in patients with Alzheimer disease. Its presence in neuritic plaques in hippocampus is especially relevant, as this is an area closely related to spatial learning and memory. In this study, the diet of wild-type and Tg2576 mice (animals overexpressing the human amyloid precursor protein) was supplemented with Al lactate (1 mg/g). General neurotoxic Al effects were evaluated using a functional observational battery and a novel object recognition task. Four experimental groups were used: Control-wild, Al-wild, Control-Tg, and Al-Tg mice. The results show a decreased home-cage activity and an increase in piloerection in all Al-exposed animals, and an increased sensorimotor reactivity in Tg2576 mice given Al. Neither Al treatment nor genotype had any noticeable effect on corticosterone levels and Al concentrations in frontal cortex and cerebellum of the mice. Recognition memory was impaired in Tg2576 mice, whereas beta-amyloid plaque depositions were observed in all these animals. However, Al did not alter the recognition memory and beta-amyloid plaque loads of Tg2576 mice.
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