期刊
ALZHEIMER DISEASE & ASSOCIATED DISORDERS
卷 22, 期 4, 页码 327-335出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WAD.0b013e31818026c4
关键词
atrophy; aging; frontotemporal dementia; frontotemporal degeneration; MRI
资金
- NIA [F32 AG022802]
- Saul A. Silverman Family Foundation
- Canada International Scientific Exchange Program
- Canadian Institutes of Health Research [53267, MT-12853, MRC-GR14974, 13129]
- University of Toronto Dean's Fund for New Faculty [457494]
- Sam and Ida Ross Memory Clinic
- James S. McDonnell Foundation [21002032]
- LC Campbell Cognitive Neurology Research Unit
- NATIONAL INSTITUTE ON AGING [F32AG022802] Funding Source: NIH RePORTER
Normal aging leads to frontocortical atrophy. The degree to which this complicates the use of frontotemporal atrophy as a diagnostic criterion for the frontotemporal dementias (FTDs) has not been reported. The present case-control study compared Frontotemporal volumes delineated with semi-automatic brain rep-ion extraction [n = 30 controls vs. 16 behavioral variant FTD (bvFTD) vs. 14 primary progressive aphasia]. Logistic regression identified those regions least helpful for distinguishing bvFTD and primary progressive aphasia from controls. Linear regression tested the correlation Of duration of illness to atrophy severity. The control group showed high variance in volumes. Controls had right frontal lobe volumes that overlapped considerably with bvFTD volumes. but. as anticipated. the left anterior temporal volumes of interest showed 91% accuracy in distinguishing the aphasic subgroup from controls. Left-sided and not right-sided atrophy in the medial middle frontal region distinguished the bvFTD group from controls. The relegation of structural imaging to a supportive criterion For diagnosis is reasonable in the context of the range of atrophy due to normal aging. While volumetry identified left-sided atrophy as useful for identifying FTD cases. future studies Should determine whether clinicians Could make these distinctions on viewing, routine diagnostic magnetic resonance imaging scans.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据