期刊
INTERNATIONAL JOURNAL OF CARDIOLOGY
卷 196, 期 -, 页码 108-114出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ijcard.2015.05.166
关键词
Dietary magnesium; Stroke; Blood pressure; Total cholesterol
资金
- University of East Anglia FMH studentship
- Medical Research Council UK [G0401527]
- Cancer Research UK [C864/A2883, C864/A8257]
- MRC [MC_UU_12015/1] Funding Source: UKRI
- Medical Research Council [MC_U106179471, G0401527, G1000143, MC_UU_12015/1] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0512-10135, NF-SI-0512-10114] Funding Source: researchfish
Background: Dietary magnesium could modify the major stroke risk factors, high blood pressure (BP) and cholesterol, but has been understudied in both sexes in a single population. This study aimed to investigate if dietary magnesium intake was associated with BP, total cholesterol (TC) and incident stroke risk in an adult population. Methods: We conducted cross-sectional analyses in a case-cohort study of 4443, men and women aged 40-75, representative of 25,639 participants years of the EPIC (European Prospective Investigation into Cancer)-Norfolk cohort. The cohort included 928 stroke cases (42,556.5 person years). Dietary data from 7 day food diaries were analysed using multivariate regression to assess associations between quintiles or data-derived categories of dietary magnesium intake and BP, TC and stroke risk, adjusted for relevant confounders. Results: We observed differences of -7 mm Hg systolic BP (P trend <= 0.01) and -3.8 mm Hg diastolic BP (P trend=0.01) between extreme intakes of magnesium in men, a significant inverse association with TC was observed (P trend=0.02 men and 0.04 women). Compared to the bottom 10%, the top 30% of magnesium intake was associated with a 41% relative reduction in stroke risk (HR 0.59; 95% CI 0.38-0.93) in men. Conclusions: Lower dietary magnesium intake was associated with higher BP and stroke risk, which may have implications for primary prevention. (C) 2015 Published by Elsevier Ireland Ltd.
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