期刊
ALLERGY AND ASTHMA PROCEEDINGS
卷 31, 期 1, 页码 20-25出版社
OCEAN SIDE PUBLICATIONS INC
DOI: 10.2500/aap.2010.31.3307
关键词
Asthma; body mass index; clinical trial; controller therapy; fluticasone propionate; inhaled corticosteroids; montelukast; obese; overweight
类别
资金
- GlaxoSmithKline
Increases in body mass index (BMI) are reported to influence asthma severity and response to treatment. This analysis was designed to explore whether increasing BMI altered the comparative response to treatment with either fluticasone propionate (FP) or montelukast. Two double-blind, randomized, parallel-group trials of 12-weeks duration comparing FP, 88 micrograms, twice daily or montelukast, 10 mg, daily Were evaluated. Subjects with mild-moderate persistent asthma were retrospectively stratified by BMI of <20 kg/m(2) (underweight), 20-24.9 kg/m(2) (normal Weight), 25-29.9 kg/m(2) (overweight), and >= 30 kg/m(2) (obese). Outcomes included mean changes in forced expiratory volume in 1 second (FEV) and morning peak flow, daily albuterol use, and daily symptom scores. There were 1052 subjects evenly distributed between FP and montelukast by baseline parameters, including BMI. FP was statistically superior to montelukast for all BMI categories of normal, overweight, and obese subjects for FEV1 (p < 0.008), morning peak flow (p < 0.002), albuterol use (p < 0.02), and symptom scores (p < 0.05). FP produced a significantly greater clinical response for normal, overweight, and obese subjects compared with montelukast. Irrespective of BMT, FP appears to be the more effective asthma controller therapy. (Allergy Asthma Proc 31:20-25, 201.0; doi: 10.2500/aap.2010.31.3307)
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