期刊
ALLERGY
卷 70, 期 3, 页码 328-333出版社
WILEY-BLACKWELL
DOI: 10.1111/all.12557
关键词
allergens; allergic sensitization; genes for atopy; poly-sensitization
资金
- European Commission [018996]
- Fondo de Investigacion Sanitaria [91/0016-060-05/E, 92/0319, 93/0393, 97/0035-01, 99/0034-01, 99/0034-02]
- Hospital General de Albacete
- Hospital General Juan Ramon Jimenez
- Consejeria de Sanidad del Principado de Asturias
- CIRIT [1997SGR 00079, 1999SGR 00241]
- Servicio Andaluz de Salud, SEPAR, Public Health Service [R01 HL62633-01]
- RCESP [C03/09]
- Red RESPIRA [C03/011]
- Basque Health Department
- Swiss National Science Foundation
- Swiss Federal Office for Education and Science
- Swiss National Accident Insurance Fund (SUVA)
- GSF-National Research Centre for Environment and Health
- Deutsche Forschungsgemeinschaft (DFG) [FR 1526/1-1, MA 711/4-1]
- Programme Hospitalier de Recherche Clinique-DRC de Grenoble [2610]
- Ministry of Health, Direction de la Recherche Clinique
- Ministere de l'Emploi et de la Solidarite
- Direction Generale de la Sante
- CHU de Grenoble
- Comite des Maladies Respiratoires de l'Isere
- UCB-Pharma (France)
- Aventis (France)
- Glaxo France
- Estonian Science Foundation. AsthmaUK
- Medical Research Council [G0801056B] Funding Source: researchfish
A number of genetic variants have been associated with allergic sensitization, but whether these are allergen specific or increase susceptibility to poly-sensitization is unknown. Using data from the large multicentre population-based European Community Respiratory Health Survey, we assessed the association between 10 loci and specific IgE and skin prick tests to individual allergens and poly-sensitization. We found that the 10 loci associate with sensitization to different allergens in a nonspecific manner and that one in particular, C11orf30-rs2155219, doubles the risk of poly-sensitization (specific IgE/4 allergens: OR=1.81, 95% CI 0.80-4.24; skin prick test/4+ allergens: OR=2.27, 95% CI 1.34-3.95). The association of rs2155219 with higher levels of expression of C11orf30, which may be involved in transcription repression of interferon-stimulated genes, and its association with sensitization to multiple allergens suggest that this locus is highly relevant for atopy.
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