期刊
ALLERGY
卷 68, 期 7, 页码 953-956出版社
WILEY-BLACKWELL
DOI: 10.1111/all.12175
关键词
CCR3; eosinophils; retinoic acids; vitamin A
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan [17790666, 21790934]
- Grants-in-Aid for Scientific Research [21790934, 25460670, 17790666] Funding Source: KAKEN
Eotaxins and their receptor CCR3 have a definitive role for tissue accumulation of eosinophils both under homeostatic and pathologic conditions. However, physiological stimuli that can up-regulate CCR3 in blood-derived human eosinophils have not been recognized. As a prior gene microarray study revealed up-regulation of CCR3 in eosinophils stimulated with retinoic acids (RAs), the expression of functional CCR3 was examined. We found that 9-cis RA and all-trans RA (ATRA) significantly induced surface CCR3 expression regardless of the presence of IL-3 or IL-5. Pharmacological manipulations with receptor-specific agonists and antagonists indicated that retinoic acid receptor- activation is critical for CCR3 up-regulation. RA-induced CCR3 was associated with its functional capacity, in terms of the calcium mobilization and chemotactic response to eotaxin-1 (CCL11). Our study suggests an important role of vitamin A derivatives in the tissue accumulation of eosinophils.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据