期刊
ALLERGY
卷 67, 期 10, 页码 1193-1202出版社
WILEY
DOI: 10.1111/j.1398-9995.2012.02880.x
关键词
airway disease; inflammation; remodeling; transforming growth factor-beta
资金
- Fund for Scientific Research Flanders (FWO-Vlaanderen) [3G.0489. 08, G.0642.10N]
- Interuniversity Attraction Poles program (IUAP) - Belgian state - Belgian Science Policy [P6/35]
- Chongqing Medical University - China
Airway diseases such as chronic rhinosinusitis, asthma, and chronic obstructive pulmonary disorder are characterized by inflammation and remodeling. Among inflammatory and extracellular matrix regulatory cytokines, transforming growth factor-beta (TGF-beta) stands central, as it possesses both important immunomodulatory and fibrogenic activities, and should be considered a key for understanding inflammation and remodeling processes. This review will briefly summarize the recent findings on the role of TGF-beta 1, from the view points of inflammation and remodeling, and discuss the role of TGF-beta in the upper and lower airway diseases. This may reveal new perspectives in the understanding of airway inflammation and remodeling processes and may open innovative treatment strategies for the regulation of TGF-beta 1.
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