期刊
ALLERGY
卷 67, 期 3, 页码 296-301出版社
WILEY
DOI: 10.1111/j.1398-9995.2011.02755.x
关键词
atopic dermatitis; environment; epidemiology; vitamin D; urticaria
Vitamin D plays key roles in innate and adaptive immunity through the stimulation of Toll-like receptors, increasing pro-inflammatory cytokine production, and possibly enhancing T helper type 2 responses. These mechanisms may explain the growing body of evidence connecting vitamin D to allergic diseases, including asthma, food allergies, and allergic rhinitis. The data relating vitamin D to allergic skin diseases are equivocal with studies linking both high and low vitamin D levels to an increased risk of developing atopic dermatitis. In this paper, we describe the role of vitamin D in the immunopathogenesis of atopic dermatitis and other allergic skin diseases.
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