期刊
ALLERGY
卷 66, 期 2, 页码 238-246出版社
WILEY
DOI: 10.1111/j.1398-9995.2010.02455.x
关键词
allergic disease; CD4 T cell; inflammation; interleukin-29; monocytes
资金
- Li Ka Shing Foundation, Hong Kong, China [C0200001]
- Major State Basic Research Program of China (973 Program) [2007CB512400]
- National Natural Science Foundation of China [30570813, 30772032]
- Natural Science Foundation of Jiangsu Province, China [BK2007730]
- Canadian Institutes of Health Research (CIHR) [191063, 177843]
- Natural Sciences and Engineering Research Council of Canada [371268]
P>Background: Interleukin (IL)-29 is a newly described cytokine that has anti-viral activity, induces tumor cell death and regulates immune function. Whether it plays a role in immune disorders is unclear. This study aims to examine the role of IL-29 in the modulation of immune response under allergic environment. Methods: A group of patients with allergic asthma or/and allergic rhinitis was recruited to this study. Serum samples were collected from the patients in both in-season and out-season; the serum levels of IL-29 were determined by enzyme-linked immunoassay. Cell types of IL-29-producing cells in upper airway mucosa were identified with immune staining and examined by immunohistochemistry and flow cytometry. Results: High serum levels of IL-29 were detected in patients with allergic asthma in in-season, but not in out-season. The majority of IL-29+ cells in upper airway tissue were CD14+ cells. Exposure to specific antigens triggered the release of IL-4 from antigen-specific CD4+ T cells; the released IL-4 activated CD14+ cells to release IL-29; the released IL-29 further triggered the release of IL-6 and tumor necrosis factor from CD4+ T cells. Conclusions: Interleukin-29 is involved in the pathogenesis of allergic inflammation via modulating immune cells' function to release proinflammatory cytokines.
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