期刊
INTERNATIONAL JOURNAL OF CANCER
卷 138, 期 3, 页码 533-539出版社
WILEY
DOI: 10.1002/ijc.29457
关键词
lung cancer; Hippo pathway; development; tumorigenesis; YAP; TAZ
类别
资金
- Canadian Institutes of Health Research (CIHR)
Lung cancer is the most commonly diagnosed cancer and accounts for one fifth of all cancer deaths worldwide. Although significant progress has been made toward our understanding of the causes of lung cancer, the 5-year survival is still lower than 15%. Therefore, there is an urgent need for novel lung cancer biomarkers and drug targets. The Hippo signaling pathway is an emerging signaling pathway that regulates various biological processes. Recently, increasing evidence suggests that the Hippo pathway may play important roles in not only lung development but also lung tumorigenesis. In this review article, we will summarize the most recent advances and predict future directions on this new cancer research field.
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