期刊
INTERNATIONAL JOURNAL OF CANCER
卷 138, 期 4, 页码 809-817出版社
WILEY
DOI: 10.1002/ijc.29564
关键词
pyruvate dehydrogenase complex; pyruvate dehydrogenase kinase; pyruvate dehydrogenase phosphatase; Warburg effect; cancer metabolism; PDK inhibitors
类别
资金
- Universite Paris Descartes
- INSERM [U1124, ITM0-cancer]
Cancer cells exhibit an altered metabolism which is characterized by a preference for aerobic glycolysis more than mitochondrial oxidation of pyruvate. This provides anabolic support and selective growth advantage for cancer cells. Recently, a new concept has arisen suggesting that these metabolic changes may be due, in part, to an attenuated mitochondrial function which results from the inhibition of the pyruvate dehydrogenase complex (PDC). This mitochondrial complex links glycolysis to the Krebs cycle and the current understanding of its regulation involves the cyclic phosphorylation and dephosphorylation by specific pyruvate dehydrogenase kinases (PDKs) and pyruvate dehydrogenase phosphatases (PDPs).
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