期刊
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
卷 30, 期 11-12, 页码 1118-1127出版社
WILEY
DOI: 10.1111/j.1365-2036.2009.04152.x
关键词
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资金
- charity GEAR (Gastrointestinal Education And Research)
- Ferring Pharmaceuticals Ltd
- Procter & Gamble Pharmaceuticals UK Ltd
- Shire Pharmaceuticals Group Ltd
P>Background Non-adherence to 5-aminosalicylic acid (5-ASA) medication can limit the established benefits of this therapy in ulcerative colitis (UC). Aim To determine rates and predictors of non-adherence to 5-ASA therapy in UC patients. Methods Medication adherence was assessed using self-report data and urinary drug excretion measurements. Participants completed a study-specific questionnaire and two validated questionnaires: Beliefs about Medicine Questionnaire (BMQ)-Specific and Satisfaction with Information about Medicines Scale. Results A total of 169 participants provided self-report adherence data; 151 also provided urine samples. Adherence rates were 111/151 (68%) according to self-report and 90/151 (60%) according to urine analysis, but the two measures were not correlated (KH2 = 0.12, P = 0.725). Logistic regression identified a significant association between self-reported non-adherence and younger age [odds ratio (OR) for increased age 0.954, 95% confidence interval (CI) 0.932-0.976] and also doubts about personal need for medication (OR for BMQ - Specific Necessity scores 0.578, 95% CI 0.366-0.913). For non-adherence based on urine analysis, only South Asian ethnicity was independently associated with non-adherence (OR 2.940, 95% CI 1.303-6.638). Conclusions Our observations confirm the difficulty of accurately assessing medication adherence. Nonmodifiable (younger age, South Asian ethnicity) and potentially modifiable (medication beliefs) predictors of non-adherence were identified.
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