期刊
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
卷 29, 期 1, 页码 97-103出版社
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1111/j.1365-2036.2008.03848.x
关键词
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资金
- Obsidian Ltd, West Glamorgan, UK
- Cultech Ltd, West Glamorgan
Background The efficacy of probiotics in alleviating the symptoms of irritable bowel syndrome (IBS) appears to be both strain-and dose-related. Aim To investigate the effect of LAB4, a multistrain probiotic preparation on symptoms of IBS. This probiotic preparation has not previously been assessed in IBS. Methods Fifty-two participants with IBS, as defined by the Rome II criteria, participated in this double blind, randomized, placebo-controlled study. Participants were randomized to receive either a probiotic preparation comprising two strains of Lactobacillus acidophilus CUL60 (NCIMB 30157) and CUL21 (NCIMB 30156), Bifidobacterium lactis CUL34 (NCIMB 30172) and Bifidobacterium bifidum CUL20 (NCIMB 30153) at a total of 2.5 x 10(10) cfu/capsule or a placebo for 8 weeks. Participants reported their IBS symptoms using a questionnaire fortnightly during the intervention and at 2 weeks post-intervention. Results A significantly greater improvement in the Symptom Severity Score of IBS and in scores for quality of life, days with pain and satisfaction with bowel habit was observed over the 8-week intervention period in the volunteers receiving the probiotic preparation than in the placebo group. Conclusion LAB4 multistrain probiotic supplement may benefit subjects with IBS.
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