期刊
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
卷 29, 期 5, 页码 589-601出版社
WILEY
DOI: 10.1111/j.1365-2036.2008.03908.x
关键词
-
资金
- University of Colorado School of Medicine, Denver, CO: [N01-DK-9-2327, M01RR-00051]
- University of California - Irvine, Irvine, CA [N01-DK-9-2320, M01RR-00827]
- Virginia Commonwealth University Health System, Richmond, VA [N01-DK-9-2322, M01RR-00065]
- New England Research Institutes, Watertown, MA [N01-DK-9-2328]
The impact of virologic response on hepatic function has not been previously defined. To determine the relationships of quantitative liver function tests (QLFTs) with virological responses to peginterferon (PEG) +/- ribavirin (RBV) in patients with chronic hepatitis C and to use serial QLFTs to define the spectrum of hepatic improvement after sustained virological response (SVR). Participants (n = 232) were enrolled in the Hepatitis C Antiviral Long-term Treatment against Cirrhosis (HALT-C) Trial, had failed prior therapy, had bridging fibrosis or cirrhosis and were retreated with PEG/RBV. All 232 patients had baseline QLFTs; 24 patients with SVR and 68 nonresponders had serial QLFTs. Lidocaine, [24-C-13]cholate, galactose and Tc-99m-sulfur colloid were administered intravenously; [2,2,4,2-H-2]cholate, [1-C-13]methionine, caffeine and antipyrine were administered orally. Clearances (Cl), breath (CO2)-C-13, monoethylglycylxylidide (MEGX), perfused hepatic mass (PHM) and liver volume were measured. Rates of SVR were 18-26% in patients with good function by QLFTs, but <= 6% in patients with poor function. Hepatic metabolism, measured by caffeine k(elim) (P = 0.02), antipyrine k(elim) (P = 0.05) and antipyrine Cl (P = 0.02) and the portal circulation, measured by cholate Cl-oral (P = 0.0002) and cholate shunt (P = 0.0003) and PHM (P = 0.03) improved after SVR. Hepatic dysfunction impairs the virological response to PEG/RBV. SVR improves hepatic metabolism, the portal circulation and PHM.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据