期刊
JOURNAL OF SUBSTANCE ABUSE TREATMENT
卷 36, 期 4, 页码 428-434出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jsat.2008.09.001
关键词
Varenicline; Smoking cessation; Tobacco dependence treatment
资金
- NCI NIH HHS [CA071358, R01 CA071358, R01 CA071358-04] Funding Source: Medline
This article examines reported symptoms, nonsmoking rates, and medication use among 1,018 smokers using varenicline in a randomized trial comparing three forms of behavioral support for smoking cessation (phone, Web, or phone + Web). One month after beginning varenicline, 168 people (17%) had discontinued the medication. Most (53%) quit due to side effects and other symptoms. The most common side effect among all users was nausea (reported by 57% of users). At 1 month post medication initiation, those not taking varenicline were more likely to report smoking than those who continued the medication (57% vs. 16%. p<.001). Women reported more symptoms but did not discontinue medication at higher rates. Participants who received any telephone counseling (n = 681) were less likely to discontinue their medication than those with Web support only (15% vs. 2%, p<.01). Counseling may improve tolerance of this medication and reduce the rate of discontinuation due to side effects. (C) 2009 Elsevier Inc. All rights reserved.
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