期刊
EUROPEAN RESPIRATORY REVIEW
卷 18, 期 112, 页码 66-79出版社
EUROPEAN RESPIRATORY SOC JOURNALS LTD
DOI: 10.1183/09059180.00000809
关键词
Activities; chronic obstructive pulmonary disease; daily living; dyspnoea; pathophysiology; respiratory mechanics
资金
- GlaxoSmithKline
- MRC [G0500411] Funding Source: UKRI
Breathlessness during daily activities has a significant impact on quality of life in chronic obstructive pulmonary disease. Herein, we present a physiological model of patientreported breathlessness based on the relationship between ventilatory load, respiratory muscle capacity, neural respiratory drive and neuromechanical dissociation during daily activities. This model should facilitate an understanding of the mechanisms driving increased intensity of breathlessness during daily activities and the relief of breathlessness following medical or surgical interventions. The model should also provide a structure on which to base the development of patientreported outcome instruments to measure the severity of breathlessness during daily activities in chronic obstructive pulmonary disease.
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