期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
卷 11, 期 1, 页码 88-98出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.10583
关键词
Liver cancer; Colon cancer; Organ site-specific metastasis; Profiling
资金
- Intramural Research Program of the Center for Cancer Research
- National Cancer Institute [Z01 BC 010313, Z01 BC 010877, Z01 BC 010876]
- National Key Project for Infectious Disease of China [2012ZX10002012-003]
- State Key Basic Research Program of China [2009CB521701]
- National Natural Science Foundation of China [81071993]
- NATIONAL CANCER INSTITUTE [Z01BC010877, Z01BC010876, ZICBC010953, Z01BC010313] Funding Source: NIH RePORTER
Metastasis is the main cause of cancer mortality but its process remains poorly understood and thus hampers more effective treatment and improved cancer prognosis. To search for metastasis driver genes responsible for tumor spread, we integrated genomic and transcriptomic profiles of 61 matched primary tumors and distant metastases of liver or colorectal carcinoma isolated by laser-capture microdissection and assayed by array-based technologies. We found that primary tumor lesions and their matched distant metastases were largely similar at the genomic and transcriptomic levels, but substantial differences could be found between primary tumors with or without accompanying metastases. Interestingly, metastasis genes were principally tumor type and organ site-specific. Despite distinct pathway enrichment, different metastasis gene sets shared common prognostic capacity and were predictive of hepatocellular carcinoma survival in an independent cohort. Thus, the metastatic propensity is inherent to the primary tumor and the lack of general metastasis genes necessitates the development of specific treatment modalities.
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