期刊
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
卷 38, 期 12, 页码 2925-2933出版社
WILEY
DOI: 10.1111/acer.12568
关键词
Brain; Addiction; Diffusion Magnetic Resonance; White Matter; Alcoholism
资金
- Translational Research Center for TBI and Stress Disorders (TRACTS) VA RRD [B6796-C]
- NIH NIAAA [14205]
- NIH [AG08796]
- NIH NINR [R01NR010827]
- NIH NIA [K23AG034258]
- NINDS [K23NS062148]
- VA Merit Review Awards
BackgroundEvidence suggests that chronic misuse of alcohol may preferentially affect the integrity of frontal white matter (WM) tracts, which can impact executive functions important to achieve and maintain abstinence. MethodsGlobal and regional WM microstructure was assessed using diffusion magnetic resonance measures of fractional anisotropy (FA) for 31 abstinent alcoholics (ALC) with an average of 25years of abuse and approximately 5years of sobriety and 20 nonalcoholic control (NC) participants. Data processing was conducted with FreeSurfer and FSL processing streams. Voxelwise processing of the FA data was carried out using tract-based spatial statistics. Clusters of significance were created to provide a quantitative summary of highly significant regions within the voxelwise analysis. ResultsWidespread, bilateral reductions in FA were observed in ALC as compared to NC participants in multiple frontal, temporal, parietal, and cerebellar WM tracts. FA in the left inferior frontal gyrus was associated with drinking severity. ConclusionsThis study found widespread reductions in WM integrity in a group of ALC compared to NC participants, with most pronounced effects in frontal and superior tracts. Decreased FA throughout the frontostriatal circuits that mediate inhibitory control may result in impulsive behavior and inability to maintain sobriety.
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