期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 72, 期 -, 页码 575-579出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2014.09.011
关键词
Talinum triangulare; Polysaccharides; Anti-diabetic effects; Hypoglycemic; Hypolipidemic
资金
- Fundamental Research Funds for the Central Universities [2013PY095]
- Clinical Research Project of Health and Family Planning Commission of Wuhan Municipality [WX13A05]
- National Undergraduate Innovative Test Program [201310504034]
The present study evaluated the anti-diabetic effects of the polysaccharides obtained from Talinum triangulare (UP). Two UP doses (150 mg/kg and 300 mg/kg.bw/d) were administered orally to normal and streptozotocin (STZ)-induced type 2 diabetic male Kunming mice, respectively. The UP hypoglycemic and hypolipidemic effects were evaluated by testing the fast blood glucose (FBG) level, fasting serum insulin (FINS), and serum lipids (TC, TG, HDL, LDL) as well as the body, hepar and kidney weights. After four weeks administration, the low-dose group 150 mg/kg.bw/d) and high-dose group (300 mg/kg.bw/d) showed a marked FBG fall rate of 29.85% and 41.18% (FBG fall rate %= ((Diabetic control - TTP group)/Diabetic control) x 100%). The results of FBG and serum lipids indicate that TTP possess significant hypoglycemic effect, but no significant hypolipidemic effect. These results suggest the potential use of UP as a functional food for the treatment of type 2 diabetic mellitus (T2DM). (C) 2014 Elsevier B.V. All rights reserved.
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