期刊
CLINICAL LYMPHOMA & MYELOMA
卷 9, 期 3, 页码 206-216出版社
CIG MEDIA GROUP, LP
DOI: 10.3816/CLM.2009.n.042
关键词
Classical Hodgkin's lymphoma; Epstein-Barr virus; HIV; Immunophenotype; Nodular lymphocyte-predominant disease; Primary mediastinal large B-cell lymphoma
类别
资金
- Center for Cancer Research, National Cancer Institute
In the past few years, there has been a greater understanding of the spectrum and biology of Hodgkin lymphoma (HL). In standard texts, HL is classified as 2 distinct entities, namely nodular lymphocyte-predominant HL and classical HL (CHL). However, recent evidence suggests that CHL is not a single disease. Although the mixed cellularity and lymphocyte-depleted subtypes might be part of a biologic continuum, the nodular sclerosis subtype has a distinct epidemiology, clinical presentation, and histology. Nodular sclerosis HL might also be related to primary mediastinal B-cell lymphoma and mediastinal gray-zone lymphomas. We present an update on the pathobiology of HL and discuss these biologic and clinical differences in this review.
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