期刊
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
卷 38, 期 1, 页码 152-160出版社
WILEY
DOI: 10.1111/acer.12224
关键词
Prenatal Alcohol Exposure; Ethanol; Serotonin (5-HT); Estradiol; Progesterone
资金
- IMPART (Canadian Institutes for Health Research STIHR)
- [R37 AA007789]
BackgroundPrevious studies on male rodents found that prenatal alcohol exposure (PAE) decreases the number of serotonin immunoreactive (5-HT-ir) neurons in the brainstem. However, data on the effects of PAE in females are lacking. In light of known sex differences in responsiveness of the 5-HT system and known effects of estrogen (E-2) and progesterone (P-4) in the brain, we hypothesized that sex steroids will modulate the adverse effects of PAE on 5-HT neurons in adult females. MethodsAdult females from 3 prenatal groups (Prenatal alcohol-exposed [PAE], Pair-fed [PF], and ad libitum-fed Controls [C]) were ovariectomized (OVX), with or without hormone replacement, or underwent Sham OVX. 5-HT-ir cells were examined in key brainstem areas. ResultsOur data support the hypothesis that PAE has long-term effects on the 5-HT system of females and that ovarian steroids have a modulatory role in these effects. Intact (Sham OVX) PAE females had marginally lower numbers of 5-HT-ir neurons in the dorsal raphe nucleus of the brainstem compared with PF and C females. This marginal difference became significant following removal of hormones by OVX. Replacement with E-2 restored the number of 5-HT-ir neurons in PAE females to control levels, while P-4 reversed the effects of E-2. Importantly, despite these differential responses of the 5-HT system to ovarian steroids, there were no differences in E-2 and P-4 levels among prenatal treatment groups. ConclusionsThese data demonstrate long-term, adverse effects of PAE on the 5-HT system of females, as well as differential sensitivity of PAE compared with control females to the modulatory effects of ovarian steroids on 5-HT neurons. Our findings have important implications for understanding sex differences in 5-HT dysfunction in depression/anxiety disorders and the higher rates of these mental health problems in individuals with fetal alcohol spectrum disorder.
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