期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 80, 期 -, 页码 23-28出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2015.05.035
关键词
Oat beta-glucan; Melanoma; Skin cancer
资金
- Statutory Funds of Wroclaw Medical University
- Polish Ministry of Science and Higher Education [Pbmn 131]
Anticancer properties of 1-3,1-4 oat beta glucan are under intensive investigation now. Antitumor characteristic of fungi and yeast beta-glucans have been widely recognized, but those polysaccharides are mostly insoluble which creates several problems especially in topical formulation. Also high molecular weight oat beta-glucans reveal high viscosity which restricts its application. According to those problems in the current study the antitumor activities of low molecular weight beta-glucan derived from oats were investigated in cancer cells: Me45, A431 and normal HaCaT and murine macrophages P388/D1. The low molecular weight beta-glucan from oat significantly deceased cancer cells viability, while for the normal cells it was non-toxic. It was observed that with the increasing incubation time and the beta-glucan concentration the cancer cells viability significantly deceased. Furthermore for the normal cells the low molecular weight beta-glucan from oat was non-toxic. Immunocytochemical ABC analysis showed that beta-glucan induced strong expression of caspase-12 in both cancer cell lines, while in HaCaT cells ABC reaction was significantly lower and in P388/D1 cell line ABC reaction was negative. Our preliminary studies show strong anti-tumor properties of new low molecular weight beta-glucan from oat and at the same time no toxicity for normal cells. (C) 2015 Elsevier B.V. All rights reserved.
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