期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 78, 期 -, 页码 189-194出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2015.03.063
关键词
Acetylsalicylic acid; Chitosan; Controlled release
资金
- Research Foundation of Shenzhen [JCYJ20120613170845998, JCYJ20140418095735550, JSD201105310228A]
- Key Laboratory of New Lithium-ion Battery Cathode and Mesoporous Materials of Shenzhen
- Natural Science Foundation of Guangdong Province [S2012040006815]
- Natural Science Foundation of China [21307083]
The acetylsalicylic acid-acylated chitosan (ASACTS) with high degree of substitution (DS) was successfully synthesized, and characterized with FTIR, H-1 NMR and elemental analysis methods. The optimum synthesis conditions were obtained which gave the highest DS (about 60%) for ASACTS. Its drug release experiments were carried out in simulated gastric and intestine fluids. The results show that the drugs in the form of acetylsalicylic acid (ASA) and salicylic acid (SA) were released in a controlled manner from ASACTS only in simulated gastric fluid. The release profile can be best fitted with logistic and Weibull model. The research results reveal that ASACTS can be a potential polymeric drug for the controlled release of ASA and SA in the targeted gastric environment. (C) 2015 Elsevier B.V. All rights reserved.
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