期刊
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
卷 36, 期 7, 页码 1230-1236出版社
WILEY
DOI: 10.1111/j.1530-0277.2011.01714.x
关键词
Alcohol; Genetics; Polymorphism; Opioid Receptor; Dependence
Background Several lines of evidence from previous research indicate that opioid receptors play an important role in ethanol reinforcement and alcohol dependence (AD) risk. Conflicting results were reported on the role of the mu-opioid receptor (OPRM1) polymorphism A118G (Asn40Asp, rs1799971) in the development of alcoholism. Methods We investigated a total number of 1,845 alcohol-dependent subjects recruited from inpatient facilities in Germany and 1,863 controls for the mu-opioid receptor (OPRM1) polymorphism using chi-square statistics. Results An association between the OPRM variant and AD was detected (p = 0.022), in recessive (AA vs. GA/GG) and co-dominant (AA vs. GA) models of inheritance. An association between the OPRM variant and the DSM-IV criterion efforts to cut down or could not (p = 0.047) was found, but this did not remain significant after the correction for multiple testing. Conclusions The results indicate that this functional OPRM variant is associated with risk of AD and these findings apply to more severe AD, although the association is only nominally significant.
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