期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 79, 期 -, 页码 830-836出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2015.04.013
关键词
Quaternary ammonium chitosan hydrogel; Gamma radiation; Antibacterial activity
资金
- National Natural Science Foundation of China [51273156, 51173143]
- Special Funds Project of Major New Products of Hubei Province [20132h0040]
- University-industry Cooperation Projects of The Ministry of Education of Guangdong province [2012B091100437]
- Ministry of Science and Technology of Small and Medium-sized Enterprises [11C26214202642, 11C26214212743]
- Zhuhai Science and Technology Plan Projects [2011B050102003]
- Wuhan Science and Technology Development [201060623262]
- Fundamental Research Funds for the Central Universities [2014-zy-220]
Quaternary ammonium chitosan (HACC)/polyvinyl alcohol (PVA)/polyethylene oxide (PEO) hydrogels were prepared using gamma radiation. The chemical structure of the hydrogels was characterized using FT-IR. The results revealed that HACC, PVA and PEO were perfectly compatible and interacted via the hydrogen bonds. As revealed by SEM, scaffolds with a homogeneous interconnected pore structure were obtained after lyophilizing the hydrogels. The influence of different radiation doses and weight ratios on properties including gel content, swelling ability, water evaporation rate and mechanical properties were investigated. It indicated that the hydrogels had the good swelling ability, water evaporation rate and mechanical properties. In vitro antibacterial activity assessment, the hydrogels exhibited a pronounced inhibitory effect against two bacteria (Staphylococcus aureus and Escherichia coli). Therefore, the hydrogels showed a promising potential to be applied as wound dressing. (C) 2015 Elsevier B.V. All rights reserved.
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