期刊
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
卷 35, 期 2, 页码 194-202出版社
WILEY
DOI: 10.1111/j.1530-0277.2010.01334.x
关键词
Alcohol Dependence; Alcohol Craving; Appetite; Feeding-Related Pathways; Sweet Preference; Feeding-Related Peptides; Neuropeptide Y; Ghrelin
Converging research evidence suggests that alcohol and food-seeking behaviors share common neural pathways. There is preclinical and clinical evidence linking the consumption of sweets to alcohol intake in both animals and humans. In addition, a growing body of animal and human literature suggests the involvement of feeding-related peptides in alcohol-seeking behavior. In particular, both central and peripheral appetitive peptides have shown a possible role in alcohol dependence. The present mini-review will summarize the literature on the link between sweet preference and alcohol dependence, and on the role of feeding-related peptides in alcohol dependence. Specifically, in an attempt to narrow the field, the present mini-review will focus on 2 specific pathways, the central neuropeptide Y and the peripheral gut peptide ghrelin. Although more research is needed, data available suggest that studying feeding-related pathways in alcohol dependence may have theoretic, biologic, diagnostic, and therapeutic implications.
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