期刊
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
卷 33, 期 8, 页码 1476-1486出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1530-0277.2009.00978.x
关键词
Major Depression; Alcohol Dependence; Drinking Motives; Genetics; Twins
资金
- National Institutes of Health [MH/AA-49492, AA/DA-09095, AA-00236]
- Carman Trust
- WM Keck, John Templeton, and Robert Wood Johnson Foundations
- National Alliance for Research on Schizophrenia and Depression
- Kellerman Fellowship in Clinical Psychology
Background: Major depression and alcohol dependence co-occur within individuals and families to a higher than expected degree. This study investigated whether mood-related drinking motives mediate the association between major depression and alcohol dependence, and what the genetic and environmental bases are for this relationship. Methods: The sample included 5,181 individuals from the Virginia Adult Twin Study of Psychiatric and Substance Use Disorders, aged 30 and older. Participants completed a clinical interview which assessed lifetime major depression, alcohol dependence, and mood-related drinking motives. Results: Mood-related drinking motives significantly explained the depression-alcohol dependence relationship at both the phenotypic and familial levels. Results from twin analyses indicated that for both males and females, the familial factors underlying mood-related drinking motives accounted for virtually all of the familial variance that overlaps between depression and alcohol dependence. Conclusions: The results are consistent with an indirect role for mood-related drinking motives in the etiology of depression and alcohol dependence, and suggest that mood-related drinking motives may be a useful index of vulnerability for these conditions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据