期刊
ALCOHOL AND ALCOHOLISM
卷 43, 期 2, 页码 192-197出版社
OXFORD UNIV PRESS
DOI: 10.1093/alcalc/agm156
关键词
-
资金
- NIAAA NIH HHS [AA-09568] Funding Source: Medline
Aims: Blood pressure (BP) changes in alcohol-dependent individuals during a 12-week alcohol relapse prevention study were examined in light of drinking status and biomarkers of alcohol consumption [carbohydrate-deficient transferrin (%CDT) and gamma-glutamyl transpeptidase (GGT)]. Methods: Of 160 randomized alcoholic individuals, 120 who had hypertension and in whom daily drinking data was available, at 6 and 12weeks of treatment were included. The impact of alcohol consumption on change in systolic BP (SBP) and diastolic BP (DBP) was examined. Further analysis determined the relationship between BP and alcohol-use biomarkers. Results: A significant effect of complete abstinence on both SBP (10mmHg; P = 0.003) and DBP (7mmHg; P = 0.001) when compared to any drinking (SBP and DBP = 1mmHg) was observed. At week 12, participants with a positive %CDT (2.6) had 7mmHg greater SBP (P = 0.01) and DBP (P0.001) than those with negative %CDT. Participants with positive GGT (50 IU) had 10mmHg greater SBP (P = 0.12) and 9mmHg greater DBP (P = 0.03) than those with negative GGT. The percent change in SBP was correlated with percent change in %CDT (P = 0.003) but not GGT (P = ns). The percent change in DBP was correlated with both percent change in %CDT (P0.0001) and GGT (P = 0.03). Conclusions: Abstinence from alcohol significantly decreased the BP and a positive relationship between BP and both alcohol-use biomarkers was illustrated. Since %CDT is more specific than GGT for heavy alcohol consumption, clinicians may monitor the role of alcohol in hypertension using %CDT as a supplemental aid, providing an objective assessment of drinking to influence BP treatment decisions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据